If Result 3 occurs, we are looking at a case of synergy between two medicines, in this case, aspirin and ibuprofen.

Please note, the preceding is just an example to illustrate different possibilities of drug combination; do not attempt to combine drugs on your own and do not use aspirin and ibuprofen together unless so advised by your physician.

Cycles have “entry” points and “exit” points for different chemical intermediates, or for materials within the cycle itself, which can also regulate the relative content of the different materials in the cycle and practically assign a clockwise or a counter-clockwise or split direction to the cycle. This is shown in Figure 4 below.

If we examine only the circle shown in Figure 4 above and ignore momentarily the other connections and routes which can influence the circle, we can see that it includes six materials, labeled A-F, which can convert into each other. Using the table below to track concentrations of the same six materials, we can see that the numbers change from Day 1 to Day 2, but the change is not unidirectional: some numbers increase and some numbers decrease.

If we keep measuring for several more days we will see that the numbers fluctuate within a certain range. Sometimes they go higher and sometimes they go lower; in response to a stimulus, they may deviate greatly from their usual range and then move back within the range soon after the stimulus is removed. Within the range, all values (high and low) are "normal"; fluctuation is the normal status for materials concentrations. When fixed values are assigned to different materials, those are labels for purposes of convenience only, for describing movement just as the numbers on a clockface are for describing the passage of time, and don’t reflect the actual dynamic state of a bio-system.

We can also see that during a metabolic disorder Material A is significantly decreased. How should this change be addressed? Traditional treatments suggest providing a stimulus to increase A. Following such a treatment B, C, D, E, or F may also respond by going awry, fluctuating outside their own range of normal concentrations because they are in the same cycle and mutually affected by each other and by A. When this happens, we must now find a treatment that will increase A but not affect B, C, D, E, or F. However, expecting to change one element of the cycle without altering the others is not realistic in most cases involving a complex bio-system.

Even if we seem to find a treatment which does not obviously affect anything other than A, it is most unlikely that we actually found such a treatment. It is more likely that we don’t see significant changes because we may not be aware yet of the way or the rate or the route in which materials are changed, or we are not looking at or detecting materials and concentrations which have changed because we don’t yet know about those materials and where to look for them. Living systems change and interact in ways we are not always able to detect, which is why much of the advancement of science has depended upon improvements in tools for observation and measurement.

So, is pushing material concentration in the opposite direction of its abnormal increase or decline the right response to a disorder? I believe that this can be a necessary approach for acute emergency situations, when a life can be saved by urgently increasing or decreasing the concentration of a material or metabolite (for example, low sodium or potassium in the blood which can cause heart failure). However, it is not appropriate for long-term treatment of mild, chronic situations, particularly when there is no emergency or life-threatening issues involved. When the concentration of Material A is abnormally swept down to the level of about 50, it is not only that A is lower, but at the same time A's ability to fluctuate in response to fluctuations of its neighboring materials B, C, D, and E is also impaired. The better solution may be not so much to directly restore the levels of A (at least, not to restore A as a primary and permanent goal) but to restore the fluctuatiion and feedback abilities of A, supporting its normal relationship with the other materials in the system.

This means that restoring A's ability to go up and down and to be responsive to its neighbors, (which, with time, will also restore its original average concentration) may be more useful than simply and directly boosting its current concentration. In addition, continuous supplementation of higher concentrations of A may not restore its average concentration over time and may actually cause more damage to the sensitive fluctuations and feedback between the different materials. The better treatment is what I call “chemical exercise” which alternates between “chemical push-ups” and “chemical pull-ups”, so that A can go up and then come down and also respond to the other materials. This exercise may eventually enable A to be restored and normalized to fluctuate within its original range of concentrations. How can this be done? By a dynamic regimen which stimulates and de-stimulates different materials in the circle in a certain frequency, as demonstrated by the Elsom Research Scalp Renewal Regimen.

What is chemical exercise therapy?

Our Scalp Renewal Regimen operates as a “chemical exercise machine” in which different ingredient gradients are introduced, removed, and reintroduced in various combinations over time. This allows the natural system to respond, adjust, counteract, compensate, and assimilate. In doing so, the scalp is exercised by ingredients gradients instead of being subjected to constant chemical assault. Within the scalp's bio-cycle, the regimen pushes and pulls and stretches and shrinks, causing materials to interact with the chemical profile of their surroundings to maximize the benefits for the scalp.

The regimen includes multiple products which are alternated on a non-constant basis. The different ingredients in each product are built to accommodate individual circles and as a whole to accommodate the entire coil or spiral. What if the ingredients in our products were formulated in medicines and could reach their appropriate targets in the scalp? Could they restore and synchronize the cascading fluctuations of the materials in the cycles and coils? Could they restore the chemical profile in dysfunctional scalp to mimic that of normal healthy adults? The answers are out there.

How do bio-cycles become bio-spirals?

The picture becomes more complicated when, as in any living creature, there is more than one bio-cycle involved. As the circles continue to fluctuate with time, they join into a coil or spiral shape which becomes elongated as more and more circles keep accumulating with time. The flow of material is normally regulated as fluctuations in material concentrations between cycles, or more rarely as a shift in the direction of a cycle. Fluctuations in materials and their varying concentrations over time can be described as a multi-cycle configuration or a coil instead of a an individual circle; this is illustrated in Figure 5 below.

In addition, many different coils are likely to be interacting with and affecting each other. This is a complex, multi-variate system, difficult to study and describe, and even more difficult to control or predict. This is why people are more attracted to the “promises” of “mechanistic” approaches which pretend to offer an elegant, pinpoint solution to a problem within a complex cascade of cycles and circles and coils for which no one has yet figured out how a change in concentration of one chemical will affect everything else.

There are many and complex potential conversion relations between different materials within a bio-system, as well as possible side-tracks and alternative metabolic routes which I will not discuss in this article. However, I would like to mention that the points of regulation of material flow in bio-cycles can be different things, including the concentrations of the metabolites which themselves comprise the cycle, or enzymes which can help the synthesis or breakdown of the metabolites, or co-factors which can regulate enzymes, or hormones which can regulate short-range and long-range cycles and coils, and others. Any tampering with cycles’ fluctuations may result in unpredictable outcome. In addition, if a regulating point is forced to remain at full activation or full deactivation for a prolonged period, the capacity for self-adjustment and fine tuning which is achieved by the ability to fluctuate can be lost and the results may be disappointing.

As mentioned above, there are cases in which emergency intervention at the metabolic level, such as when insulin- manufacturing cells have not only been diminished but completely destroyed, and other acute, life-threatening problems. For many long-term problems or deficiencies which are mostly connected with reduced metabolic balance rather and do not entail risk to continued life, the treatment should be to restore balance rather than to directly push some single parameter up or down.

How can combining multiple topicals into a bio-rhythmic dynamic synergy regimen offer more benefits than using the same topicals individually?

At Elsom Research, we design our individual cosmeceuticals to be very powerful. Many of them are built with internal chemical synergy, so the ingredients support each other in addition to accomplishing their independent tasks. Also, we have long recommended our products to be used as pairs or triplets or quadruplets. For example, using our scalp serums NanoScalp^® and JuveLine™ on alternating days allows each to have maximum contact with the scalp without interfering with the other.

By designing a 24-week regimen, we introduce a new concept of synergy which can be achieved as a long-term goal, where increasing or decreasing a metabolic function is not the main goal but rather a secondary potential outcome. The main goal is to resume normal material fluctuations along with the time-sensitive changes in the coils-continuum network. This is a higher level of support for the bio-system than is possible by addressing changes in time within a given cycle, as is already achieved by using our cosmeceuticals as individuals or sets.

How is dynamic synergy implemented in Elsom Research topical formulations?

There are some topical skincare treatments which have positive effects and benefits but they all have one problem: they are not dynamic, meaning that they are not designed to correlate with natural shifts of the bio-rhythm. Over the course of many years at Elsom Research, we have introduced many topicals with internal synergism which work at the top performance level of any topicals available and though they have different and sometimes seemingly-contradictory directions they were all beneficial. We can now say that we have been building up a new treatment concept for many years, and have found a way to ensure that a combination of different topicals, each with different benefits, can be dynamically combined and disconnected during a six-month period to give the best of results and to be as biologically friendly and as bio-rhythm sensitive as possible, and to work in a way which will not cause the treatment fatigue which is common to high-dose, uni-directional treatments. We believe that the same products which did so much good individually or in simpler combinations will deliver an extra high level of quality and quantity effects when combined in dynamic synergy.

In implementing dynamic synergy, we temporarily separate between our cosmeceuticals as well as temporarily combine them in our regimen. The temporary separation is as important as the later combination. Separating products is part of the treatment as much as combining them. Biological cycles are rarely addressed in conventional treatments, most of which are designed as if every day in the human body were identical to every other day; in medicine, contraceptive hormone treatments , designed to interfere with bio-rhythms, are an exception to this. The Elsom Research dynamic synergy scalpcare regimen is designed in short-term repetitive cycles and long-term non-repetitive spirals.

When a biological cascade is awakened it will not normally go back to sleep immediately after the treatment stops. The awakening effect will last for a while; you can then go and wake up other bio-cascades and get back to the first one after a while. This will create a large spectrum of activation and re-balancing between all these awakened cascades and they will respond more naturally to each other and to treatments. Since such a concept is many years away from implementation in medicine (Medicine must be regulated, and how can a non-linear process even be regulated to start with?), the only area open to such applications is via skincare and scalpcare topicals where the problems they address are not diseases and their effects are not medicinal.

To see a complex demonstration of dynamic synergy, combining a variety of treatments over an extended period, examine the six-month dynamic synergy scalpcare regimen defined for eight Elsom Research scalpcare cosmeceuticals. That regimen lays out a pattern for use of the eight topicals as illustrated here

Similar dynamic synergy regimens are planned for Elsom Research skincare cosmeceuticals in the near future